Palmitoyl Tripeptide-5 200mg

Due to their ability to interact with sensitive skin, cosmetic peptides started to stand out as one of the go-to ingredients in the skincare industry. Another thing making them stand out even more, is the fact they are highly potent even at lower dosages.

One such peptide is palmitoyl tripeptide-5, which you can buy at Peptide.Shop.

What Is Palmitoyl Tripeptide-5?

This is a synthetic peptide which mimics the sequence of the protein Thrombospondin I (TSP-1) fragment, presenting the sequence N-(1-oxohexadecyl)-L-lysyl-L-valyl-L-lysine.

Initially, this tripeptide was produced with the help of solid-phase synthesis. But, since this mode of production caused significant cost and pollution to the environment, two different liquid methodologies were introduced. 

What Does It Do?

Palmitoyl Tripeptide-5 was hypothesized to reduce metalloproteases (MMP’s) expression and pro-inflammatory cytokine synthesis; these effects result in vasodilation and increased capillary permeability. 

This is why this cosmetic peptide was first used as an ingredient in products designed to reduce skin redness in type I rosacea. It was also used in anti aging cosmetic products, formulas for sensitive skin, as a type I and II collagen synthesis promoter, as well as a melanin production inhibitor (aimed at reducing tyrosinase activity).

How Effective Was Palmitoyl Tripeptide-5?

As mentioned through the text, for some of these studies we only have the basic information and can not conclusively say how effective this tripeptide really was. Luckily, we have one animal study done in vitro, that showed Palmitoyl Tripeptide-5 therapy significantly decreased collagen breakdown process. 

References:

https://pmc.ncbi.nlm.nih.gov/articles/PMC8400021/

Tao Y., Chen J., Wang X. Method for Efficiently Preparing Palmitoyl Tripeptide-5 Based on Activated Ester. CN110423264A. 2020 Dec 1;

Ziegler H., Heidl M., Imfeld D. Tripeptides and their derivatives for cosmetic applications for improving skin structure. WO2004099237A1. 2004 Nov 18;

DSM Launches Regu-Cea. [(accessed on 7 May 2021)]; Available online: https://www.happi.com/contents/view_breaking-news/2009-04-22/dsm-launches-regu-cea/

Milanello S. REGU®-CEA: Approccio multifunzionale contro i sintomi della rosacea. Kosmetica. 2009:56–58. [Google Scholar]

Liao Y., He L., Liu X., Liu Y. Composition for Repairing Sensitive Skin, and its Application in Cosmetic. CN109010113A. 2018 Dec 18;

Lu X., Dai C., He H., Liang J., Tang Z. Multifunctional Toning Lotion and its Preparation Method. CN111632001A. 2020 Sep 8;

Ji X., Lin J., Wang L. Preparation Method of Dried Facial Mask Comprising Ceramide-2 and Traditional Chinese Medicine Extract for Caring Skin. CN109350591A. 2021 May 25;

Avcil M., Akman G., Klokkers J., Jeong D., Çelik A. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. J. Cosmet. Dermatol. 2020;19:328–337. doi: 10.1111/jocd.13009.