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GHRP-2, a synthetic growth hormone secretagogue, selectively binds to the ghrelin/growth hormone secretagogue receptor. Through various research trials, it has shown the ability to enhance muscle growth, regulate the immune system, and positively influence sleep cycles. Notably, GHRP-2 exhibits oral bio-activity, making it effective without the need for injections.
This PRODUCT IS INTENDED FOR RESEARCH PURPOSES ONLY. Its usage should be limited to in vitro testing and laboratory experimentation. This product is not intended for any other purposes, including but not limited to medical, therapeutic, or diagnostic applications. It must not be used on humans, animals, or any living organisms.
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What is GHRP-2?
GHRP-2, also referred to as pralmorelin, is a synthetic growth hormone secretagogue that specifically targets the ghrelin/growth hormone secretagogue receptor. It was the pioneering growth hormone secretagogue and is currently available as a test peptide to evaluate growth hormone deficiency and secondary adrenal failure.
In stage II clinical trials, GHRP-2 has been explored as a potential remedy for short stature. Additionally, ongoing research is actively investigating its impacts on various aspects such as appetite, muscle growth, the immune system, and sleep cycles.
A notable advantage of GHRP-2 is that it exhibits both oral and sublingual activity, eliminating the necessity for injections to induce its effects.
Molecular Formula: C45H55N9O6
Molecular Weight: 817.9749 g/mol
PubChem CID: 6918245
CAS Number: 158861-67-7
Code Names: KP-102, GPA-748, WAY-GPA-748
1. Protects and Enhances Muscle Structure
Studies conducted on Yaks have revealed that GHRP-2 can significantly enhance muscle growth through two mechanisms: by increasing protein deposition and simultaneously decreasing protein degradation. These findings have particularly important implications for overcoming natural growth plateaus experienced by yaks during periods of food scarcity, disease, or harsh environmental conditions like cold temperatures.
A crucial discovery from this research is that GHRP-2 effectively counteracts muscle atrophy by deactivating two key proteins, atrogin-1 and MuRF1, which regulate the muscle degradation pathway. This exciting finding holds promise for potential applications in reducing catabolism, which is commonly observed in chronic illnesses such as autoimmune diseases and cancer.
Notably, GHRP-2 also activates the growth hormone and insulin-like growth factor-1, further contributing to enhanced muscle protein deposition. The combined effect of reducing degradation and promoting deposition enables GHRP-2 to foster the development of lean body mass, even in challenging and unfavorable circumstances. These results offer valuable insights into the potential benefits of GHRP-2 for muscle growth and maintenance, particularly under adverse conditions.
2. Stimulates Appetite
Research has demonstrated that GHRP-2 has the capacity to increase food intake. While this effect might not appear immediately crucial, in the context of chronic disease, stimulating appetite becomes a significant aspect of comprehensive healthcare. The ability to effectively and consistently boost appetite could aid doctors in treating patients with chronic illnesses and potentially lead to improved long-term outcomes.
Food intake in healthy adult men, placebo versus GHRP-2
3. May Protect the Heart
Studies conducted on fetal heart cell culture lines have revealed that GHRP-2 and its analogues, namely GHRP-1 and GHRP-6, exhibit a protective effect by reducing apoptosis or programmed cell death. This finding holds particular significance in the context of heart attacks, where heart cells are highly vulnerable to apoptosis due to reduced blood flow and nutrient supply.
Moreover, research employing an analogue of GHRP-2 called Hexarelin has provided valuable insights, suggesting the existence of a specific receptor for these peptides.
The discovery of new receptors in various tissues not only opens avenues for novel drug development but also deepens our understanding of human physiology and offers potential strategies to prevent dysfunction in the first place. This line of research has promising implications for advancing cardiac care and enhancing our knowledge of cellular mechanisms involved in safeguarding heart health.
4. Improves the Immune System
Research shows GHRP-2 possesses the ability to stimulate the thymus, an essential organ responsible for safeguarding certain immune system cells. Specifically, the thymus plays a vital role in maturing T cells, which are crucial for adaptive immunity and our capacity to combat complex infections.
As individuals age, the function of the thymus naturally declines, resulting in various age-related dysfunctions. These range from impaired tissue repair to diminished immunity, leading to an increased susceptibility to infections, reduced cancer defenses, and compromised tissue functionality.
However, excitingly, GHRP-2 has shown the potential to rejuvenate the thymus by enhancing both the quantity and diversity of T-cells it produces . Consequently, this leads to a significant improvement in immunity, offering promising prospects for strengthening the body’s defense mechanisms against diseases and maintaining overall health.
Change in number of active T-cells following administration of GHRP-2
5. Improves Sleep Quality
Studies have revealed that GHRP-2 can extend the duration of stages 3 and 4 of sleep cycles by approximately 50% each, while also increasing REM sleep by around 20%. Simultaneously, it reduces deviations from “normal sleep” by as much as a third. This overall improvement in sleep has been associated with enhanced cognitive function, better blood pressure regulation, improved healing processes, and increased energy levels .
These findings are valuable for all adults, but they hold particular significance for the elderly population, where the effects of aging often impact sleep quality. GHRP-2 offers potential insights into how to optimize sleep patterns, potentially enabling individuals to reap the benefits of a full night’s sleep in a significantly reduced timeframe.
Understanding and fine-tuning sleep with the aid of GHRP-2 could lead to substantial advancements in improving sleep quality, thereby benefiting overall health and well-being. Additionally, it may offer hope for addressing sleep-related issues experienced by various age groups, providing potential solutions to enhance restorative sleep and its associated benefits.
6. May Affect Pain Perception
Originally, scientists believed that the reduction in pain observed in animal models of osteoarthritis when treated with GHRP-2 was a result of its ability to boost growth hormone levels and accelerate tissue healing. However, keen researchers noticed that pain relief occurred before significant healing, indicating that GHRP-2 might directly influence pain perception. Further investigations revealed that GHRP-2 interacts with opioid receptors .
There are four known opioid receptors, and most traditional opioid pain medications affect all of them without discrimination. This lack of selectivity creates issues because some receptors mediate pain relief, while others impact functions such as wakefulness, breathing, and addiction. In contrast, GHRP-2 acts as a selective opioid receptor agonist, primarily binding to the receptors responsible for pain relief, sedation, and addiction. This discovery opens up the possibility of developing specific opioid agonists, which could help mitigate or entirely avoid undesirable effects like respiratory depression and addiction.
In animal studies, GHRP-2 has shown minimal to moderate side effects, and it exhibits good subcutaneous bioavailability when administered orally. However, the dosage in mice is not directly scalable to humans. Therefore, GHRP-2 available for purchase at Peptide Shop is strictly limited to educational and scientific research purposes, not for human consumption. Only licensed researchers should consider buying GHRP-2 for their studies.
The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.
Scientific Journal Author
Jean-Alain Fehrentz was born in Nancy, France, in 1955. He received his Ph.D. degree in Chemistry from the University of Nancy in 1983 and joined the Centre CNRS-INSERM de Pharmacologie Endocrinologie of Montpellier in the research group of Professor B. Castro. From 1989 to 1992 he was appointed as researcher at Sanofi Research in Montpellier. Then he moved to the Faculty of Pharmacy of Montpellier, working under the direction of Professor J. Martinez. His research interests focus onpeptide aldehydes, enzyme inhibitors, peptidomimetics, growth hormone interactions, and heterocycle based receptor ligands. He has published more than 150 scientific papers.
Jean-Alain Fehrentz is being referenced as one of the leading scientists involved in the research and development of GHRP-2. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Shop and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Jean-Alain Fehrentz is listed in under the referenced citations.
|Dimensions||10 × 10 × 20 mm|