GHRP-6 10mg

What Is GHRP-6?

GHRP-6 is a potent stimulator of Growth Hormone Release from the anterior pituitary gland. Additionally, it functions as a ghrelin/growth hormone receptor agonist, belonging to a group of ghrelin analogues developed in recent years. The peptide has shown favorable effects on various aspects of the body, including heart muscle cells, memory formation, scar healing, sex motivation, and the neurons related to Parkinson’s disease. Notably, GHRP-6 is active when administered orally or sublingually and exhibits moderate to high selectivity for its target receptors.

GHRP-6 Structure

Source: PubChem

Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys
Molecular Formula: C₄₆H₅₆N₁₂O₆
Molecular Weight: 873.032 g/mol
PubChem CID: 9919153
CAS Number: 87616-84-0

GHRP-6 Effects

1. Improves Memory

For quite some time now, researchers have actively explored the connection between physical activity and its impact on learning and memory formation. While the precise mechanism has remained elusive, there has always been a belief that physical activity enhances cognition and learning, particularly when performed immediately after a learning task.

Initially, the cognitive benefits of exercise were attributed to improved blood flow and references to growth hormone (GH) without clear explanations. However, studies in rodents have shed light on why GH may play a significant role in memory formation. It has been discovered that GHRP-6, a substance that influences GH release, can contribute to solidifying newly formed memories and converting short-term memories into long-term storage[1], [2].

Furthermore, compelling evidence supports the notion that ghrelin/GHRP-6 also influences spatial learning tasks[3]. This suggests that the cognitive benefits induced by exercise might be mediated through growth hormone secretagogues like ghrelin, and that the GH effect may be indirect and possibly secondary to the actions of these peptides.

2. Protects Brain Tissue

GHRP-6’s potential in safeguarding neurons and other cells in the central nervous system from the consequences of insufficient blood supply is explored using animal models of stroke. Remarkably, GHRP-6 not only provides protection to brain tissue during the acute phase of stroke but also exhibits the ability to rescue memory deficits if administered promptly after the stroke[4], [5]. It appears that ghrelin and its analogues effectively inhibit apoptosis (programmed cell death) and reduce inflammation in the brain. This dual action shields neurons from the impacts of both genetic programming and the adverse surroundings that occur following a stroke.

Pathway by which ghrelin inhibits apoptosis and reduces inflammation
Source: PubMed

3. Protects Parkinson’s Neurons

A 2018 study shed new light on GHRP-6’s potential to safeguard brain tissue, particularly in relation to Parkinson’s disease. The study revealed the presence of ghrelin receptors in the substantia nigra, a brain region affected by Parkinson’s. Notably, individuals with known genetic connections to Parkinson’s exhibit reduced expression of ghrelin receptors on substantia nigra neurons. Similarly, rats with this deficiency display Parkinson’s-like symptoms when given an antagonist injection.

This suggests that GHRP-6 and other agonists may hold promise in Parkinson’s treatment. Researchers speculate that these peptides, by binding to the diminished receptors, could potentially reduce neuronal apoptosis in the substantia nigra and possibly slow down or even prevent the onset of Parkinson’s disease.

4. Improves Skin Appearance and Reduces Scaring

GHRP-6 exhibits remarkable cell-protective properties by reducing programmed cell death, leading to improved survival in various cell types. Additionally, the peptide interacts with the CD36 receptor, known for promoting blood vessel growth, especially in wound healing. In rat studies, these properties have proven highly beneficial for wound healing, as GHRP-6 accelerates wound closure, enhances the formation of vital extracellular matrix proteins like collagen, and disrupts the typical scar formation process. This results in a better overall wound structure and diminished scar tissue appearance[7].

Furthermore, GHRP-6 has demonstrated its ability to prevent the development of hypertrophic scars, a condition similar to keloids, characterized by improper extracellular matrix protein deposition. This discovery is particularly advantageous for individuals suffering from this abnormal healing process, as it alleviates concerns about undergoing surgery or medical procedures that may lead to painful scars and significant aesthetic alterations[8].

5. Reduces Heart Problems

Studies conducted on porcine models of heart attack reveal that GHRP-6 has the potential to prevent oxidant cytotoxicity, effectively shielding heart cells from damage caused by free radicals[9]. This significant finding raises optimism for the development of drugs that could be administered after a heart attack to safeguard vulnerable but still viable cells. Such a drug has the potential to decrease mortality and enhance long-term outcomes in the aftermath of a heart attack.

6. Alters Sex Motivation and Mood

Research in male rats indicates that ghrelin receptors in the central nervous system affect sexual behavior and motivation. Elevated levels of ghrelin, for instance, can boost sexual motivation. Research with GHRP-6 and a modified GHRP-6 designed to antagonize the ghrelin receptor has indicated that ghrelin receptors in specific brain regions help to modulate sex behavior and reward-seeking behavior. These findings are not only applicable to sex and conditions like hypoactive sexual desire disorder, but may also be applicable to hunger and other types of motivation.

There is also evidence to suggest that ghrelin may impact mood as part of its effect on motivation. Research in mice indicates that GHRP-6 and other ghrelin receptor agonists can decrease depression and improve function in parts of the brain associated with mood, particularly in the setting of stress. GHRP-6 could form the basis for research into potential novel treatments for stress, anxiety, depression, and other mood disorders.

GHRP-6 exhibits minimal to moderate side effects, low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice does not scale to humans. GHRP-6 for sale at Peptide Shop is limited to educational and scientific research only, not for human consumption. Only buy GHRP-6 if you are a licensed researcher.

Article Author

The above literature was researched, edited and organized by Dr. Logan, M.D. Dr. Logan holds a doctorate degree from Case Western Reserve University School of Medicine and a B.S. in molecular biology.

Scientific Journal Author

Márta Korbonits graduated in Medicine in Budapest and undertook her early clinical training at the Internal Medicine Department of the Postgraduate Medical School, Budapest. She joined the Department of Endocrinology at St. Bartholomew’s Hospital under the mentorship of Professors Ashley Grossman and Michael Besser. Her MD and later PhD studies contributed to the understanding of the effects of growth hormone secretagogues on hypothalamic hormone release and the nature and causes of pituitary tumorigenesis. She was awarded an MRC Clinician Scientist Fellowship and commenced studies that produced novel insights into ghrelin physiology and genetics.

Her findings related to the regulation of the metabolic enzyme AMPK by ghrelin, cannabinoid and glucocorticoid opened a new aspect of hormonal regulation of metabolism. In 2008, Márta Korbonits was promoted to Professor of Endocrinology and Metabolism and since 2012, has led the Centre of Endocrinology at Barts and the London School of Medicine. In 2016, Márta Korbonits was appointed a Deputy Head of the William Harvey Research Institute. Professor Korbonits continues to integrate human studies alongside with laboratory-based research and has pioneered several projects in translational medicine.

Márta Korbonits is being referenced as one of the leading scientists involved in the research and development of GHRP-6. In no way is this doctor/scientist endorsing or advocating the purchase, sale, or use of this product for any reason. There is no affiliation or relationship, implied or otherwise, between Peptide Shop and this doctor. The purpose of citing the doctor is to acknowledge, recognize, and credit the exhaustive research and development efforts conducted by the scientists studying this peptide. Márta Korbonits is listed in [12] under the referenced citations.

Resourced Citations

1. C.-C. Huang, D. Chou, C.-M. Yeh, and K.-S. Hsu, “Acute food deprivation enhances fear extinction but inhibits long-term depression in the lateral amygdala via ghrelin signaling,” Neuropharmacology, vol. 101, pp. 36–45, Feb. 2016.
2. S. Beheshti and S. Shahrokhi, “Blocking the ghrelin receptor type 1a in the rat brain impairs memory encoding,” Neuropeptides, vol. 52, pp. 97–102, Aug. 2015.
3. K. Tóth, K. László, and L. Lénárd, “Role of intraamygdaloid acylated-ghrelin in spatial learning,” Brain Res. Bull., vol. 81, no. 1, pp. 33–37, Jan. 2010.
4. N. Subirós et al., “Assessment of dose-effect and therapeutic time window in preclinical studies of rhEGF and GHRP-6 coadministration for stroke therapy,” Neurol. Res., vol. 38, no. 3, pp. 187–195, Mar. 2016.
5. S. J. Spencer, A. A. Miller, and Z. B. Andrews, “The Role of Ghrelin in Neuroprotection after Ischemic Brain Injury,” Brain Sci., vol. 3, no. 1, pp. 344–359, Mar. 2013.
6. Y. Suda et al., “Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction,” Mol. Brain, vol. 11, no. 1, p. 6, 20 2018.
7. Y. Mendoza Marí et al., “Growth Hormone-Releasing Peptide 6 Enhances the Healing Process and Improves the Esthetic Outcome of the Wounds,” Plastic Surgery International, 2016. [Online]. Available: https://www.hindawi.com/journals/psi/2016/4361702/. [Accessed: 23-May-2019].
8. M. Fernández-Mayola et al., “Growth hormone-releasing peptide 6 prevents cutaneous hypertrophic scarring: early mechanistic data from a proteome study,” Int. Wound J., vol. 15, no. 4, pp. 538–546, Aug. 2018.
9. J. Berlanga et al., “Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction,” Clin. Sci. Lond. Engl. 1979, vol. 112, no. 4, pp. 241–250, Feb. 2007.
10. L. Hyland et al., “Central ghrelin receptor stimulation modulates sex motivation in male rats in a site dependent manner,” Horm. Behav., vol. 97, pp. 56–66, 2018.
11. H.-J. Huang et al., “The protective effects of Ghrelin/GHSR on hippocampal neurogenesis in CUMS mice,” Neuropharmacology, May 2019.
12. Korbonits, Marta, and Ashley B. Grossman. “Growth Hormone-Releasing Peptide and Its Analogues.” Trends in Endocrinology & Metabolism, vol. 6, no. 2, Mar. 1995, pp. 43–49

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The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: in glass) are performed outside of the body.  These products are not medicines or drugs and have not been approved by the FDA to prevent, treat or cure any medical condition, ailment or disease.  Bodily introduction of any kind into humans or animals is strictly forbidden by law.