BPC-157 and TB-500 are synthetic peptides of different peptide chain lengths and different origins, but with very similar beneficial properties. Their mechanisms of action complement each other, creating their full potential. Their application is primarily related to injuries to connective tissues (muscles, joints, or bones). In addition, peptides individually achieve special properties, such as the bpc 157 muscle growth effect, which has found particular clinical application. Scientists assume that the best way to administer these peptides is through subcutaneous injections, which patients with significantly reduced symptoms confirm.
BPC 157 Peptide Benefits
Body Protection Compound-157 (BPC-157) is a synthetic peptide composed of fifteen amino acids and is derived from longer natural proteins from gastric juice. The paramount ability of this compound is an excellent regenerative potential, mainly expressed in connective tissues such as ligaments, muscles, or tendons. In addition, the anti-inflammatory property of this peptide is crucial because it allows its use in both severe and mild inflammatory conditions, and can also improve muscle recovery.
BPC 157 has shown significant effects on the gastrointestinal system in clinical studies, improving the recovery of the intestinal mucosa and preventing the formation of ulcers. Benefits of bpc 157 also include cytoprotective effect, which is particularly pronounced in nervous tissue, where this amino acid sequence can reduce neuronal damage and accelerate recovery after severe ischemic conditions such as stroke.
These properties make BPC 157 very potent in treating tendon and ligament injuries. In addition, muscle injuries such as strains or sprains respond very well to this peptide, and improvement occurs very quickly. If you have any joint problems or severe digestive problems (gastritis, irritable bowel syndrome, or inflammatory bowel disease), this peptide may be an excellent solution for you.
TB 500 Peptide Benefits
TB 500 is a synthetic peptide consisting of seventeen amino acids and is a fragment of the natural protein Thymosin Beta-4 that is naturally secreted in your body. This peptide is potent in tissue regeneration by accelerating wound healing, and can also help treat joint, ligament, and tendon injuries, accelerating recovery after injury. If you have any inflammatory condition, it will not limit the use of this peptide, because TB 500 has anti-inflammatory effects and angiogenesis properties (the creation of new blood vessels), so its use will be equally effective in you and other patients. Similar to BPC 157, this peptide can aid in recovery after cerebrovascular conditions.
However, the clinical use of this peptide is most often in cases of muscle injury, such as tearing or stretching of muscle fibers, chronic injury to joints, tendons, or bones. Compared to the previous peptide, the TB500 peptide benefits also include possible improvements in cardiovascular health, and it is also used in treating eye injuries. If you’ve ever wondered what is TB 500 used for, now you know the answer to that question.
How BPC 157 and TB 500 Work?
The mechanism of action of these two peptides is the same, but specific differences make them ideal in combination. BPC 157 stimulates the synthesis of fibroblasts (the primary cells of connective tissue) by activating various signaling pathways that are crucial for the migration and proliferation of these cells. This peptide changes the surrounding environment so that it is favorable for the survival of fibroblasts. One of the ways this effect is achieved is by regulating the production of NO (Nitric Oxide), as well as reducing the oxidative stress present.
In addition to fibroblasts, collagen fibers (most often type I) are also stimulated. When these connective components arrive at the site of injury in larger quantities, they significantly accelerate recovery and affect the regeneration of your joints, ligaments, or tendons.
By activating the vascular endothelial growth factor (VEGF) signaling pathway, this peptide rapidly induces angiogenesis (the growth of new capillaries), which allows for a significantly improved flow of oxygen and glucose through arterial blood. This effect is crucial because it significantly accelerates the process of connective tissue repair.
The anti-inflammatory effect is achieved by stimulating the synthesis of anti-inflammatory cytokines (IL-4, IL-10) and inhibiting the synthesis of pro-inflammatory cytokines (IL-1, IL-6, TNF-α), thereby shifting the balance towards calming inflammation.
The mechanisms of action of TB 500 peptides are very similar, especially in terms of achieving angiogenesis, neuroprotective role, and anti-inflammatory effect. However, when it comes to the basic regenerative effect, it is partially different. This peptide binds G-actin, which does not stimulate fibroblast formation to a large extent, but increases cell motility. After binding, certain modifications occur on the cytoskeleton, which are responsible for the accelerated movement of the primary cells of the connective tissue (fibroblasts, keratinocytes, collagen fibers), towards the site of injury.
The Effect of the Combined Administration of Two Peptides
The mechanism of action and the roles of these two peptides are very similar, but in combination, they act in a complementary manner. This fact is especially evident when it comes to the mechanism of action of achieving regenerative potential. BPC 157 works by creating ideal conditions at the site of injury, by improving blood circulation, increasing the number of blood vessels, and reducing inflammation. Under such conditions, a significantly faster and higher-quality synthesis of fibroblasts and collagen occurs.
These connective cells regenerate your injured tissue and restore the function that you lost due to the injury.
Following the beneficial effects of BPC-157, TB-500 leads to increased cell mobility and migration at the site of injury. Now your injured tendon, joint, or ligament is flooded with connective cells, which will regenerate them and accelerate your recovery.
Angiogenesis co-occurs with both peptides. However, BPC 157 maintains the quality of existing ones and additionally contributes to the formation of new ones, while TB 500 works on the activation and migration of endothelial cells. The combined effect results in adequate vascularization, so large amounts of nutrients and oxygen are delivered to your injury to repair the condition.
The anti-inflammatory effect, which is stimulated by both peptides with specific differences, complements the therapy and leads to significantly better results. So, if inflammatory disease complicates your injury or is itself inflammatory, a combination of these peptides may help you.
Scientific studies have shown that the combination of these two peptides achieves significantly better effects than the independent use of either compound. Their simultaneous effects lead to an improvement in the condition of connective tissue quickly and effectively, and the accompanying properties in combination can improve the health of other organ systems, such as the cardiovascular or nervous system.
The use of these peptides also carries certain risks that are usually very mild and short-lived. Separately, BPC-157 side effects include nausea, dizziness, or the injection site reactions. In contrast, TB-500 shows similar side effects and some additional ones, such as allergies, increased body temperature, or mild tachycardia.
Application of BPC 157 and TB 500 in Regenerative Medicine
Regenerative medicine is a branch of medicine that deals with the repair of a specific injury to an organ or tissue to restore complete function. Unlike regeneration, reparation is also a state of repair of a damaged organ or tissue. Still, the injured part is filled with connective tissue (scar tissue) and, therefore, is not functional in later life. In medicine, we always strive to achieve a higher degree of regeneration, rather than reparation.
In clinical practice, regenerative medicine often emphasizes protein and peptide therapy, as it is the least invasive option, with a developed treatment plan and the potential to reduce patient symptoms and ease daily activities significantly. BPC 157 and TB 500 are among the peptides with strong regenerative potential, and the idea of combining them came after learning that their properties are similar, but are achieved through entirely different mechanisms of action.
Some of the crucial indications for the use of this peptide combination include joint diseases such as osteoarthritis, autoimmune rheumatoid arthritis, or sports injuries (most commonly meniscus injuries, tendon or ligament sprains). In addition to joints, muscles are often affected, where muscle ruptures, tendon injuries, fibromyalgia, or myofascial pain most often occur. Other chronic idiopathic conditions also require rehabilitation, such as long-term sports injuries in runners, swimmers, or weightlifters.
If you have any of these diagnoses, you are probably familiar with terms like cartilage degeneration, muscle fiber tearing, bone reduction, and various others. Whatever the type of connective tissue involved (cartilage, muscle, or bone), all patients with these conditions have in common the loss of the basic cells of that type of tissue (chondrocytes, myocytes, or osteoblasts).
Since BPC157 and TB 500 are peptides for healing, scientists believe that their joint use could harness their full regenerative potential and significantly increase the number of underlying tissue cells. In this way, your injury (ruptured muscle, torn ligaments, or damaged bone) fills with mature connective cells, completely restoring the tissue’s original function.
Patients who were part of a human clinical trial, after applying the combination of these two peptides, noticed significant relief, a reduction in symptoms such as pain, swelling, or difficulty moving. In addition, after a short time, they were able to perform all daily and sports activities without any problems, which means that tissue function had returned to its original level.
Application of the Combination of TB 500 and BPC 157 in the Future
If clinical trials on humans and additional experimental studies confirm the expected effects, the mass application of combinations of these two peptides is expected in the future. In addition, the development of newly observed potential impact is expected, such as a possible effect on reversing fibrosis and reducing scarring. If this property is confirmed through experimentation, combined peptide therapy could find its use in the postoperative course, as an additional therapy that will enable a faster and better quality recovery. In addition, complications after extensive interventions on large organs could be minimized.
Although both peptides have neuroprotective effects and protect neurons from damage, this effect has not yet reached its potential. Scientists believe that it could be improved and used daily as an adjunct therapy in treating ischemic conditions of the brain and spinal cord, such as ischemic stroke, cerebrovascular disease, or peripheral circulatory disease.
Rehabilitation applications and regenerative potential are the most researched and have already found their use in everyday medical practice, but their further improvement is expected in the future.
Conclusion
BPC 157 and TB 500 are synthetic peptides of different origins, with very similar beneficial effects. Their mechanisms of action are complementary, so scientists are increasingly favoring their joint use to achieve the full effect. The primary clinical application of this peptide is the field of regenerative medicine, which includes diagnoses such as diseases of the joints, muscles, bones, or ligaments. Scientists suggest that if used according to instructions, and in an optimal dosage, BPC-157 + TB-500 can achieve significant results. If you have ever hesitated about which peptide is the right choice for you, there is no more dilemma, it is their combination.
Some users wonder if peptides are even legal to use for research. Our post Are peptides illegal?
dives into the legal status of peptides across different regions and applications.
References:
- Bock-Marquette, I., Saxena, A., White, M. D., Dimaio, J. M., & Srivastava, D. (2004). Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature, 432(7016), 466–472. https://doi.org/10.1038/nature03000
- Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., Vuletic, L. B., Drmic, D., … & Mise, S. (2010). Stable gastric pentadecapeptide BPC 157: a novel antiulcer peptide and cytoprotector. Current Pharmaceutical Design, 17(16), 1612–1632. https://doi.org/10.2174/138161211796196955
- Zupancic, B., Brcic, L., Gojkovic, S., Kralj, T., Vranes, H., & Sikiric, P. (2021). BPC 157 and the healing of tendon, ligament, muscle and bone injuries: a review of mechanisms and clinical evidence. Journal of Applied Physiology, 131(1), 15–26. https://doi.org/10.1152/japplphysiol.00208.2021
- Goldstein, A. L., Hannappel, E., & Kleinman, H. K. (2005). Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues. Trends in Molecular Medicine, 11(9), 421–429. https://doi.org/10.1016/j.molmed.2005.07.007
- Chang, Y., Wei, W., Wang, P., Zhang, Y., Zhang, Q., & Tang, C. (2017). Thymosin β4 promotes angiogenesis and improves myocardial function after infarction in rats. Molecular Medicine Reports, 15(1), 379–387. https://doi.org/10.3892/mmr.2016.6005
- Barisic, D., Sikiric, P., Seiwerth, S., Rucman, R., Kolenc, D., & Vuletic, L. B. (2015). The influence of BPC 157 on muscle healing impaired by systemic corticosteroids. Medical Science Monitor, 21, 419–426. https://doi.org/10.12659/MSM.892676
- Cerovecki, V., Bojanic, I., Brcic, L., Radic, B., Vukojevic, K., & Sikiric, P. (2010). BPC 157 and Achilles tendon healing in rats: biomechanical, microscopical, and functional evaluation. Journal of Orthopaedic Research, 28(6), 865–871. https://doi.org/10.1002/jor.21057
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