GHK-Cu is also known as the human copper tri-peptide. GHK-Cu is a naturally occurring peptide, and it’s particularly interesting to researchers due to its anti-inflammatory and antioxidant properties and the fact it gets released from tissue after injury.
Even though it was initially thought that GHK-Cu only binds copper ions, the prevailing idea now is that it can up and down regulate genes involving injuries and stress response.
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GHK-Cu is an extraordinary peptide widely recognized and sought after for its great regenerative and anti-aging capabilities. It is made of a tripeptide called GHK bound to a copper ion. It seems that copper ion stabilizes and delivers GHK to cells.
Clinical trials suggest that GHK-Cu may play a crucial role in wound repair, restoring damaged tissue, and boosting immune response. These hypotheses indicate that GHK-Cu could potentially stimulate the production of glycosaminoglycans, elastin, and collagen.
This peptide may also have anti-inflammatory and antioxidant properties that protect cells from free radical damage.
Clinical trials indicate that GHK-Cu may enhance collagen synthesis and stimulate tissue recovery. Scientists suggest that these actions may be caused by the presence of GHK triplets, which are located at the alpha two chains of type one collagen.
Specifically, the tripeptide sequence is made of glycine, histidine, and lysine and may be divided during collagen breakdown via hydrolysis. This breakdown is commonly linked to the disintegration of collagen fibers, frequently resulting from the natural degradation process or tissue damage.
It is suggested that this specific peptide sequence may have a crucial impact on the cellular communication process, mostly targeting fibroblasts. These fibroblast cells are considered essential in generating new collagen fibers, significant components for structural support in different tissues.
The interaction between this tripeptide sequence and fibroblast could initiate a series of biological events leading to collagen synthesis, thereby playing a crucial role in regeneration and tissue repair. A study that lasted for a year reported that GHK-Cu has the ability to stimulate type one collagen production in clinical settings. Scientists compared GHK-Cu peptide to other peptides and vitamins like A and C on photodamaged skin, and they found that GHK-Cu improved all indications, such as cutaneous inflammation, differentiation, keratinocyte proliferation, and dermal procollagen synthesis.
Both clinical and animal studies have suggested that GHK-Cu could minimize the risk of infection and inflammation in wounds. A study that investigated the effects of this peptide on rodents’ ischemic open wounds found that this compound could potentially affect both tissue remodeling and inflammatory processes.
Therefore, GHK-Cu is recognized for its healing properties and might have an important role in preventing tissue breakdown and minimizing inflammation in cases of ischemic wounds, where restrictions in blood flow cause tissue damage.
A clinical trial that included GHK-Cu in addition to standard wound care found that this peptide was able to reduce the risk of infection compared to the standard process alone.
A study has been conducted on rabbits, and scientists tested GHK-Cu’s potential in wound healing along with laser exposure at various intensities. They compared the results with control wounds without intervention. Researchers observed wounds daily and took biopsies every week for four weeks to examine neovascularization and inflammation rate.
The high-intensity laser and GHK-Cu group seem to have a shorter average healing time and faster filling of an open wound with granulation tissue, which wasn’t the case with the control group. Granular tissue appears on the wound surface and forms minuscule blood vessels and connective tissue as part of the healing process.
A 2013 study looked at the activity of Argireline, a synthetic analog of the N-terminal portion of the SNAP-25 peptide. Researchers tested it in normal murine models and altered diabetic models. In both, researchers found that dressing wounds with collagen and administering them with GHK appeared to improve wound healing considerably.
In a span of three weeks, the biotin GHK-treated wounds that were a tripeptide known for their regenerative effects on the skin were nearly fully closed, with a closure rate of 99.39%. This was a stark contrast to the 69.49% closure rate in the control dressings that lacked the peptide.
Skin and tissue photoaging has, in the majority of cases, been ascribed to the production of reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive carbonyl species (RCS). These reactive substances possess the potential to damage cells by acting against proteins, DNA, and lipids. According to research, the amino acid structure of GHK-Cu possesses the potential to counteract RCS and eradicate radicals such as 4-hydroxynoneal, acrolein, and malondialdehyde. Furthermore, GHK-Cu can potentially be involved in inhibiting protein glycation, an activity that is linked with aging and cellular decline.
The other potential function of GHK-Cu is that it can modulate iron release from ferritin. Since ferritin is a peroxidative catalyst for lipids, extensive release of iron in damaged tissues has the ability to increase inflammation. Experiments have shown that GHK-Cu can inhibit this action by inhibiting iron complex formation, thus reducing oxidative stress. One study even reported an 87% inhibition of iron release upon the addition of GHK-Cu, showing its potential to reduce tissue oxidation and damage.
Apart from its antioxidant activity, GHK-Cu has also been linked with a reduction of reactive oxygen species and the release of inflammatory cytokines with increased activity of major antioxidant enzymes. In one animal model of its action against lipopolysaccharide-induced mouse lung inflammation, GHK-Cu was conjectured to inhibit the NF-κB and p38 MAPK signaling pathways, both being inflammatory. Consequently, treated mice had reduced levels of TNF-1 and IL-6 and fewer inflammatory cell infiltration, suggesting a potential protective action against lung injury.
References:
GHK-Cu 200mg
4ghk-cu 200mg
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