Pentapeptide-18 belongs to the group of neurotransmitter peptides and is associated with the SNAP-25 receptor protein (SyNaptosome-Associated Protein, 25 kDa). This receptor protein is involved in the release of acetylcholine and the formation of SNARE (SNAP receptors) complex.
Pentapeptide-18 affects the neuromuscular synapses and, by binding to these synapses, it closes up the calcium channels, which results in the reduction of acetylcholine release. Acetylcholine is responsible for muscle contractions and the formation of wrinkles; so, by blocking it, researchers believe they can affect the formation and the severity of wrinkles.
Some added Pentapeptide-18’s benefits, that the researchers noticed, was its ability to hydrate the skin and improve its firmness. Of course, more research is still needed, but the initial findings are pointing in the right direction.
Reference:
https://pmc.ncbi.nlm.nih.gov/articles/PMC11432460/
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