PT-141, also known as Bremelanotide (generic clinical name), is a highly altered synthetic derivative of alpha-melanocyte-stimulating hormone, which acts as an agonist for the melanocortin-4 and melanocortin-1 receptors.
The main characteristics of PT-141 is that it non selectively targets MCRs, including MC1R (which is shown to increase melanin expression), as well MC4R and MC3R (expressed in the central nervous system, affecting brain pathways related to sexual response).
Its action is also linked to general dopamine release in the brain which affects sexual stimulation.
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