SLU-PP-332 Overview
Replicating the health benefits of exercising with pharmaceuticals has so far been a search for the holy grail. And when you logically think about it, and about these health benefits such as:
- Staying fit
- Fighting obesity
- Improving cardiovascular health
- Improving mental health and
- Fighting off disease
it does make sense that you can’t obtain these unless you engage in exercise. The good thing about those of you who don’t like exercising is, this trend is slowly starting to change.
This change was reflected in one of the most recent peptides developments in the form of semaglutide which, not only helps patients patients with type 2 diabetes and blood sugar control, but also speeds up the metabolism, helps with metabolism regulation, and overall results in a significant weight loss without the need for a rigorous exercise regime.
As the research and breakthroughs continue, we’re seeing peptides becoming even more powerful and producing other incredible health benefits.
SLU-PP-332 is the direct product of these breakthroughs - an estrogen-related receptor agonist that’s been shown to improve skeletal muscles endurance, cardiovascular health and boost weight loss. Practically speaking, this peptide is the closest thing we go to mimicking the effects of exercise, without actually exercising.
Note that, even though the results we’ve seen are promising, these results were observed in animal studies - at the time of writing, we haven’t seen any clinical studies with human test subjects.
What Is SLU-PP-332?
SLU-PP-332 is an estrogen-related receptor agonist that activates three types of these receptors:
These receptors regulate gene expression patterns which impact energy levels, oxidative metabolism, and mitochondrial biogenesis. In other words, activating these receptors:
- Elevate energy expenditure
- Increase exercise tolerance and physical endurance
- Improve fatty acid oxidation
- Improve muscle tone
- Improve cardiovascular health
- In other words, they induce the positive benefits of an actual physical exercise
SLU-PP-332 Research Studies
We already said that there were no human research studies conducted (at the time of the writing); but there are plenty done on mice, so we’re going to talk about three we found most exciting and promising:
- This study was conducted on diet-induced and genetically obese mice, in which SLU-PP-332 was administered to mimic the metabolic benefits typically associated with physical exercise. The results clearly showed weight reduction and reduced fat accumulation in these obese mice, but without an exercise regime or food intake reduction. (source)
- This second study, also done on mice, showed that those that were administered with SLU-PP-332 showed enhanced exercise endurance, increased oxidative skeletal health muscle fibers, mitochondrial function and cellular respiration. In other words, mice got better at handling physical exercise without the physical exercise stimuli. (source)
- Last but not least, one of the more recent studies, presented by the American Chemical Society (source) showed that SLU-PP-332 improved cardiac function in rats suffering from heart failure. It does so by enhancing mitochondrial ultrastructure and upregulating oxidative phosphorylation pathways.