Syn-AKE is a synthetic polypeptide known for its anti-aging and wrinkle-reducing properties, which make it a go-to addition to various skincare products. Syn-AKE, also known as “snake peptide”, by design mimics the venom of the Temple Viper snake (Tropidolaemus wagleri), which has the ability to temporarily paralyze the snake’s prey by completely blocking its muscle contractions. In small organisms such as mice and other rodents, this causes complete muscular paralysis, while in humans, this effect is localized, much less apparent, and, if applied in adequate dosage, completely harmless. Therefore, Syn-AKE aims to replicate this particular property while being completely lab-made.
Syn-AKE is produced by a process known as Solid Phase Peptide Synthesis (SPPS), which consists of individual amino acids added onto each other to form a sequence. A solid support medium, such as resin, ensures the addition of individual amino acids to a growing chain. After the sequence has been completed, the chain is modified by adding certain functional groups onto it to ensure its stability, effectiveness, and skin absorption rate.
Once the desired molecule has been created, it is then purified by removing the unwanted segments and byproducts through the process of High-Performance Liquid Chromatography (HPLC). The purified Syn-AKE molecule is then emulsified with other ingredients, such as a moisturizer and stabilizer into a finished product, often in the form of a cream, lotion, serum, or other topical formulation. This entire process leaves us with a finished product that is stable, effective, and ready to use.
Benefits Of Using Syn-AKE For Anti-Aging Compared To The Alternatives
Among the many positive qualities of Syn-AKE, its numerous advantages over alternatives are the major factors responsible for its growing popularity. The main alternative to Syn-AKE is botulinum toxin, widely known as Botox, an injectable neurotoxin that is used for a similar effect on local muscle paralysis in order to achieve a more smooth and youthful appearance of the face. However, Syn-AKE has shown to be far superior to Botox in several aspects. Most importantly, Syn-AKE is completely non-invasive, as it is an ingredient of topically applied products in various forms, while Botox is injected subcutaneously. This makes it far more user-friendly, as there is no need for a medical professional and additional equipment such as needles and syringes, so it can be safely used at home and applied directly by the user.
When it comes to the mechanism of action, Syn-AKE, similarly to Botox, reduces muscle contractions and, therefore, reduces the number of wrinkles and other fine lines on the skin. However, the effects are way more gradual and subtle, which results in a more natural movement and appearance of the face. Botox, on the other hand, can often result in a stiff and “frozen” appearance of the face when applied excessively.
Besides their anti-wrinkle properties, Syn-AKE products also have antioxidant and moisturizing properties, which can help with the skin’s texture, structure, tone, and hydration. Therefore, they are suitable for most skin types, including the sensitive skin. Syn-AKE is generally much more cost-effective, as there is no need for repeated professional treatments and a single package of a product containing Syn-AKE may last for a longer time.
Current Research on Syn-AKE
It has been over a decade since the beginning of the commercialization of Syn-AKE, and therefore, numerous studies have been conducted in order to investigate the properties of this peptide and test its effectiveness and overall safety for the user. Several recent studies have proven Syn-AKE and the products containing it to be highly beneficial for the reduction of wrinkles and an overall improvement in the quality and appearance of facial skin while being biocompatible and safe for use.
Research from 2022 has focused on developing a novel Syn-AKE peptide that inhibits the action of Acetylcholine (ACh) by binding to nicotinic acetylcholine receptors. This leads to muscle relaxation and wrinkle reduction. Several other clinical studies have demonstrated significant improvements in wrinkle appearance after using this novel peptide.
Another study from 2023 explored the interactions of Syn-AKE molecules with Sirtuin 1 (SIRT1) and Matrix Metalloproteinases (MMPs), both of which are directly linked to anti-aging mechanisms. This study also showed the antioxidant properties of Syn-AKE and its overall safety and biocompatibility using various in vitro methods.
An article from 2023 discusses the efficacy of using products containing peptides such as Syn-AKE as a non-invasive alternative to Botox injections. Clinical investigations have shown that a 4% Syn-AKE formulation can reduce the wrinkle size by more than 52% over a 4-week period.
Summary
Syn-AKE, also known as “snake peptide”, is a lab-made polypeptide with the goal of replicating the locally paralytic effects of the Temple Viper snake’s venom on facial muscles. This particular property has made it a revolutionary option for treating wrinkles and improving the overall appearance and quality of the skin. Syn-AKE peptide is emulsified with different ingredients, such as moisturizer and stabilizer, into topically applied products, such as creams, lotions, and serums.
Nowadays, Syn-AKE is widely known as a promising alternative to the more expensive anti-wrinkle solutions such as Botox, being more cost-effective, less invasive, and more beneficial for multiple aspects of the skin. Numerous studies have proven its efficacy, biocompatibility, and overall safety for the user.
Resources:
- Balaev, A. N., Okhmanovich, K. A., & Osipov, V. N. (2014). A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake exploiting an optimized Hofmann-type rearrangement. Tetrahedron Letters, 55(42), 5745-5747.
- Molles, B. E., Tsigelny, I., Nguyen, P. D., Gao, S. X., Sine, S. M., & Taylor, P. (2002). Residues in the epsilon subunit of the nicotinic acetylcholine receptor interact to confer selectivity of waglerin-1 for the alpha-epsilon subunit interface site. Biochemistry, 41(25), 7895–7906. https://doi.org/10.1021/bi025732d
- Gorouhi, F., & Maibach, H. I. (2009). Role of peptides in preventing or treating aged skin. International journal of cosmetic science, 31(5), 327–345. https://doi.org/10.1111/j.1468-2494.2009.00490.x
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- Reddy, B. Y., Jow, T., & Hantash, B. M. (2012). Bioactive oligopeptides in dermatology: Part II. Experimental dermatology, 21(8), 569–575. https://doi.org/10.1111/j.1600-0625.2012.01527.x
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