Tesamorelin is one of the most potent synthetic growth hormone-releasing (GHRH) analogues. It is based on the GHRH amino acid sequence that has been modified for potency and extended half-life. Tesamorelin also stimulates insulin-like growth factors.
Ipamorelin, besides aiding in growth hormone release, is a ghrelin mimetic, meaning it mimics the action of ghrelin. Ghrelin is a hormone which plays an important role in regulating food intake and appetite overall.
So, the combination of these two peptides offers an interesting synergistic effect where they, on the one hand, boost growth hormone secretion and affect appetite and food intake, on the other.