We live in an age where peptides are valuable resources that seem to affect well-being and quality of life to a great extent. Since peptides gained popularity, Tesamorelin and Sermorelin have become almost inseparable components of many lifestyle and wellness industries being researched for their benefits.  

Their potential impact on general well-being is normally connected to many crucial factors for a good quality of life in general. How do they work their magic? In this review, let us get inside-out knowledge of their benefits, differences, and dosage of these peptides.

Peptides in General 

These short chains of amino acids are naturally found in our bodies and they are a shorter chain version of proteins. Peptides generally consist of 2 to about 50 amino acids. The sequence and composition of these amino acids determine the peptide’s specific function. Peptides are vital to many biological functions and have gained attention for their potential benefits. Some of the most well-known peptides on the market are Tesamorelin and Sermorelin. Now, let’s discuss what they are all about. 

What is Tesamorelin? 

This powerful peptide is a synthetic peptide designed to stimulate the release of a particular hormone that plays a key role in various processes. It is composed of 44 amino acids as well as a trans-3-hexenoic acid group. The latter acid group makes Tesamorelin more stable and longer-lasting. That means that the use of Tesamorelin can be less frequent, as the effects last for a prolonged period of time. 

It is primarily used to address specific conditions related to metabolic imbalances. Enhancing the body’s natural mechanisms can lead to beneficial outcomes, and balance out vital functions. 

Sermorelin

Talking about the Sermorelin peptide, it is an older, better-researched, and shorter synthetic peptide than Tesamorelin. Similarly to Tesamorelin, its success started in the medical field as a natural supplement. Regardless of its immediate success, its manufacturer discontinued its production due to the lack of commercial potential, and Sermorelin was taken off the FDA-approved peptide list. 

Nevertheless, it has never stopped attracting attention and has been studied for its natural stimulation of hormones and impact on anything from relieving the process of aging to general emotional and physical well-being. Sermorelin peptide cost and availability make it an important research peptide to look for, keeping in mind a reliable supplier as it is as it has not been strictly regulated.

What are They Known for?

Overall, both of these peptides can lead to a more balanced hormonal environment, which can have various advantageous impacts on general health. Mostly, both Tesamorelin and Sermorelin are known as anti-aging peptides. Even though they do differ in the mechanisms of impact, their most notable benefits connected to anti-aging are: 

Mood

Improved mood has been reported as one of the benefits of experiencing reductions in feelings of fatigue or lethargy, leading to a more positive outlook. By stimulating the release of specific hormones, these peptides can boost self-esteem and confidence, further supporting a better mood.

Sleep Quality

Sleep enhancement is likely one of the most well-known Sermorelin’s power. This peptide can help restore and allow for deeper, more refreshing sleep. In the modern age, staying asleep and feeling more alert during the day the effects Sermorelin may offer are invaluable.

Improved Skin Health

Aging is known for causing our body’s collagen levels to drop, leaving the skin thinner and drier. According to some earlier studies, Sermorelin might help synthesize collagen and restore skin regeneration and youthfulness.  More balanced metabolic health and increased energy levels can contribute to a more vibrant appearance.

Anti-Aging

In a search to turn back the hands of time and harness the power of science to combat aging, understanding the nuances of these two compounds becomes crucial. After the mid-thirties, the collagen levels start to drop. To keep our valuable youthful properties, additional help is needed. This is where peptides can play a significant role. 

The peptides trigger visible body changes like facial wrinkles and loss of skin elasticity, and less visible but equally important ones like fatigue, and slower metabolism. Even without sufficient research evidence to support this, Sermorelin has been considered an anti-aging peptide for its probable effect on reversing some visible symptoms of aging like improving skin elasticity and impacting the overall energy levels.

Tesamorelin peptide vs Sermorelin

Let’s take a closer look at their differences:

Tesamorelin has a slightly different structure compared to Sermorelin, which affects its potency and duration of action. Sermorelin consists of 29 amino acids, as opposed to 44 in Tesamorelin, which means that it is generally processed more easily. 

Some studies speculate that Tesamorelin has a half-life of just 30 minutes. In other words, its effects can last for up to two weeks. Similar data is not available for Sermorelin.

Each peptide has its unique applications and effects. Tesamorelin is usually used for specific conditions, while Sermorelin may benefit a broader range of issues. 

Where to Buy Tesamorelin and Sermorelin

If looking to buy peptides in the USA for research purposes, it’s important to choose a reputable source to ensure that they are offering peptides of the best safety and quality properties, since research peptides do not follow strict medical regulations.  

Reputable companies should be open about sourcing, manufacturing processes, and ingredient origins. Look for companies with positive reviews and a strong reputation in the industry. User testimonials and third-party reviews can provide insights into reliability. Always prioritize safety and quality when seeking peptides for research purposes. 

To Conclude

In the market striving for innovations, peptides like Tesamorelin and Sermorelin are undergoing different research studies to discover and improve their structure and make them even more beneficial. 

References:

1. G. Price and D. A. Patel, “Drug Bioavailability,” in StatPearls, Treasure Island (FL): StatPearls Publishing, 2022. Accessed: 10. 10, 2024. [Online]. Available: https://www.ncbi.nlm.nih.gov/books/NBK557852/
2. S. Khaleghi, J. M. Ju, A. Lamba, and J. A. Murray, “The potential utility of tight junction regulation in celiac disease: focus on larazotide acetate,” Ther. Adv. Gastroenterol., vol. 9, no. 1, Art. no. 1, Jan. 2016
3. R. F. Walker, “Sermorelin: a better approach to management of adult-onset growth hormone insufficiency?,” Clin. Interv. Aging, vol. 1, no. 4, Art. no. 4, 2006
4. Clinical Review Report: Tesamorelin (Egrifta). in CADTH Common Drug Reviews. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health, 2016. Accessed: Apr. 06, 2022. [Online]. Available: http://www.ncbi.nlm.nih.gov/books/NBK539131/
5. J. E. Lake et al., “Tesamorelin improves fat quality independent of changes in fat quantity,” AIDS Lond. Engl., vol. 35, no. 9, pp. 1395–1402, Jul. 2021, doi: 10.1097/QAD.0000000000002897.
6. Landsmann MA. Forever young? What role does human growth hormone play in the aging process? The question is rife with controversy. ADVANCE for Healthy Aging. 2006
7. Merriam GR, Barness S, Buchner D, et al. Growth hormone releasing hormone treatment in normal aging. J Anti-Aging Med. 2001;
8. Wikipedia the Free Encyclopedia. (2023, January 28). Sermorelin. Wikipedia. Retrieved February 14, 2023, from <https://en.wikipedia.org/wiki/Sermorelin
9. Villalobos C, Núñez L, Frawley LS, et al. Multi-responsiveness of single anterior pituitary cells to hypothalamic-releasing hormones: A cellular basis for paradoxical secretion. Proc Natl Acad Sci U S A. 1997;94:14132–7. doi: 10.1073/pnas.94.25.14132.