Vesugen (Bioregulator) 20mg

Vesugen is a peptide also known as KED, is a tripeptide that specifically acts on the vascular system. It’s derived from a specific amino acid sequence - lysine, glutamic acid, and aspartic acid (Lys-Glu-Asp) and first identified by a russian scientist Vladimir Khavinson.

Vesugen’s importance lies in the fact that it affects endothelial vascular cells, lining the interior surface of blood vessels (which act as a selective barrier, help regulate blood flow, oxygen delivery etc). Since its discovery, there have been numerous studies investigating Vesugen’s potential in addressing and treating other conditions related to aging, neuroprotection and vascular biology.

How does Vesugen Work?

Vesugen works by interacting with vascular endothelial cells. We already said that these cells are crucial in maintaining the integrity of the blood vessels, blood flow regulation, oxygen delivery, and nutrient facilitation.

But its effects go beyond blood vessels… subsequent research demonstrated this tripeptide’s ability to interact with processes within the cells themselves, involved in cell survival and repair. This is why scientists are hopeful for this peptide’s future, they believe it will be a factor in fighting atherosclerosis and restenosis, neuron survival and neuroplasticity.

Neuroplasticity is especially important in fighting neurodegenerative diseases, so further research is necessary before considering Vesugen as a candidate for FDA-approved therapy purposes.

Vesugen and Blood Vessels

Since its discovery, Vesugen has been of interest to scientists due to its vasoprotective properties, effects on aging, and general vascular function. It is speculated that it affects vascular endothelial cells proliferation and division, by regulating protein Ki-67. This protein declines with age, resulting in reduced endothelial renewal capacity; and this is why scientists believe Vesugen will be one of the key peptides to boost this renewal capacity in the future.

What Vesugen does is it interacts with the Ki-67 gene promoter regions, leading to its increased expression. This increased expression is what, later, leads to the vascular cell proliferation. This mechanism of action will be important in identifying future treatment options for degenerative vascular conditions, vascular endothelial problems, vascular lesions, or atherosclerosis. Some researchers also believe that Vesugen may directly interact with certain DNA regions that are responsible for Ki-67 expression, opening a window in epigenetic Ki-67 regulation, meaning, Vesugen therapy will not cause/lead to any changes in DNA but will be able to regulate gene expression.

Furthermore, research studies showed Vesugen normalized the expression of endothelin-1. Endothelin-1 molecule is linked to atherosclerosis or restenotic conditions (medical situations where a narrowing/blockage of a blood vessel occurs after the vessel has already been treated for a previous blockage). This combination is very interesting and gives researchers hope and motivation for further research, as Vesugen was shown to both boost endothelial proliferation and reduce atherosclerosis potential.

Vesugen In Neuroprotection

Research suggests Vesugen possesses some neuroregenerative capabilities as it was able to support cognitive functioning, synaptic plasticity restoration, as well as connection strengthening.

The list of positive effects does not stop there, Vesugen was also shown to influence the genes associated with apoptosis (programmed cell death), protein and neural differentiation, and even genes associated with Alzheimer’s Disease.

When we consolidate all these findings and clinical trial results, we come to a very favorable conclusion for Vesugen:

• It promotes neuronal survival and delays cell apoptosis
• Boosts cell growth and differentiation
• Normalizes genes associated with neurodegenerative conditions (such as Alzheimer’s disease)
• And even counteract the neurotoxic effects generated under low oxygen conditions

Vesugen In Aging

Clinical research showed Vesugen has the ability to affect cellular aging markers. Namely, it exhibits anabolic influence which promotes cellular growth, synthesis and essentially mitigates the cellular aging process and delays apoptosis.

Besides anti-aging properties, Vesugen was also shown to stimulate the process of autophagy (indirectly) - a process where damaged cells and cellular components are recycled, renewed, and removed.

Vesugen In Metabolic Regulation

Clinical trials showed Vesugen’s association with protein sirtuin 1 (SIRT1), a protein linked to insulin sensitivity. Latest murine model studies (laboratory mice) showed when the protein sirtuin 1 gets activated (using Vesugen peptide in this case), test subjects insulin sensitivity decreases and insulin resistance becomes mitigated.

But that’s not all. The final conclusions in these studies were that SIRT1 stimulation does not only improve insulin sensitivity, it has the implication towards resolving insulin resistance problems as a whole and managing type 2 diabetes.

Conclusion

We’ve covered a lot of ground and done through some of the most researched benefits associated with Vesugen therapy options. These studies suggest that:

• It helps with blood vessels
• Positively affects aging and cell death
• Promotes neuroprotection and plasticity
• And even helps with metabolic regulation

One thing worth mentioning is that Vesugen is still in its testing stages, it has not yet been approved by FDA as a treatment option for any of the diseases and medical conditions we’ve outlined here.

This is why Vesugen sold at Peptide.shop is meant for research purposes only - laboratory use and not human consumption.

References:

1. Khavinson V, Ilina A, Kraskovskaya N, Linkova N, Kolchina N, Mironova E, Erofeev A, Petukhov M. Neuroprotective effects of tripeptides‑epigenetic regulators in mouse model of Alzheimer’s disease. Pharmaceuticals (Basel). 2021;14(6):515. English. PMID: 34071923

2. Sinjari B, Diomede F, Khavinson V, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S. Short peptides protect oral stem cells from ageing. Stem Cell Rev Rep. 2020;16(1):159–166. English. PMID: 31677028

3. Kozlov KL, Bolotov II, Linkova NS, Drobintseva AO, Khavinson VK, Dyakonov MM, Kozina LS. [Molecular aspects of vasoprotective peptide KED activity during atherosclerosis and restenosis]. Adv Gerontol. 2016;29(4):646-650. Russian. PMID: 28539025.

4. Wang R‑H, Kim H‑S, Xiao C, Xu X, Gavrilova O, Deng C‑X. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest. 2011 Nov;121(11):4477–4490. English. PMID: 21965330

5. Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. Adv Gerontol. 2015;28(1):62-7. Russian. PMID: 26390612.