Also called Palmitoyl Tripeptide-3, Pal-AHK is a synthetic peptide which consists of three amino acids – Alanine, Histidine and Lysine, with the addition of palmitoyl group. Just like when we were talking about Pal-GHK, the added palmitoyl group serves as a “vessel” that aids the bundled amino acids to penetrate the stratum corneum and enter the tissue. This added Pal group makes the entire compound fat soluble, increasing the overall absorption and effectiveness.
Pal-AHK Research Application
We still don’t have many human studies, so we have to rely heavily on animal ones. These animal studies tell us that Pal-AHK has the ability to activate fibroblasts (a type of cell which contributes to the formation of the connective tissue), increasing the rate of extracellular matrix production within the skin.
Since the extracellular skin matrix is abundant in collagen and elastin cells, by boosting it, Pal-AHK raises collagen and elastin levels, improving skin appearance and tightness.
Some of these animal studies also pointed out that the Pal-AHK molecule affects the production of vascular endothelial growth factor (VEGF), crucial in new blood vessels production. Increased vascularity in the skin improves its physical appearance and rejuvenates in.
Speaking of skin appearance, we already talked about Pal-AHK’s ability to boost collagen and elastin levels; this, coupled with increased skin penetration, allows for wrinkles and fine lines appearance reduction, improvements in the appearance in age spots, skin tone and texture, as well as improvements in the overall skin smoothness. Of course, we’re only talking about animal models, we have yet to see some conclusive human studies.
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