SNAP-8 is a mimetic of the N-terminal end of SNAP-25 (SyNaptosome-Associated Protein). SNAP-8 competes with its 25 counterpart for a position within the SNARE complex and, by doing so, changes its formation. SNARE complex (SNAP REceptors complex) primary role is to mediate the fusion of vesicles with the target membrane. Some of these vesicles contain neurotransmitters responsible for botulism and tetanus, suggesting that the SNARE complex affects muscle contractions and prevents fine lines from being formed.
SNAP-8 is a synthetic peptide that mimics the effects of botulinum. Unlike botulinum which stops the release of chemical acetylcholine (which makes the muscles contract), SNAP-8 disrupts the SNARE complex. This will, then, prevent the release of acetylcholine and prompt temporary muscle relaxation.
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