Tripeptide-29 is a synthetic peptide which utilizes a three-chain amino acid sequence that mimics one of the basic building blocks of collagen. When speaking of collagen, we should point out that it’s a natural protein found in skin and all internal organs; but it’s not only a structural protein, it also plays a role in cell adhesion, tissue regulation and healing.
Tripeptide-29, thus, acts as a building block of large collagen molecules and may impact multiple physiological features.
SHARE:
Products sold on our website are designed for in vitro testing and lab experimentation exclusively.
All the products you see on the website are being sold in a lyophilized powder state (freeze-dried), in a sealed sterile vial; and should be reconstituted.
The product’s label clearly states the amount of product a vial contains; some products are offered in different variations.
The products we are selling come in a sealed vial but require additional lab equipment for proper testing.
Tripeptide-29, although small in its structure, is one of the main building blocks for collagen protein. Collagen is an important part of the extracellular matrix, the network of fibers and proteins that make connective tissue. It is responsible for offering support and structure to cellular complexes.
Scientists believe that Tripeptide-29 could stimulate collagen synthesis and promote collagen fiber formation. In addition to collagen synthesis, this peptide potentially has other biological functions. For instance, research studies underline its potential as an antioxidant, which might protect cells from damage and oxidative stress. It may also display anti-melanogenic, anti-fibrotic, and anti-inflammatory properties.
Recent research involving short peptides like Tripeptide-29 has shown that they can be used to manage the stability of collagen. Tripeptide-29 has helped researchers understand that the last peptide mainly influences the ultimate collagen structure in a tripeptide monomer.
In the spectrum of A-B-C, Tripeptide-29 is in the C position, which has the biggest impact on collagen stability. This finding could assist scientists one day in developing synthetic impacts for teeth, bone, cartilage, and more.
Free radicals directly cause tissue and cellular aging. While the body has numerous ways to fight against free radical damage, they all become less effective as we age. Research conducted on sea cucumbers revealed that collagen hydrolysates composed of monomers such as Tripeptide-29 are effective radical scavengers. Even though no research has been carried out on Tripeptide-29, there is an interest in finding out how this peptide could be used in nutraceutical products and food.
In vitro clinical studies of chick feet, fish scales, and cattle skin have revealed that Tripeptide-29 is an inhibitor of (DPP4) dipeptidylpeptidase-IV activity. DPP4 is an enzyme mostly found in cells linked to cell apoptosis and immune signaling.
It is an inseparable part of the cell membrane and indiscriminately destroys vasoactive peptides, neuropeptides, chemokines, and growth factors. DPP4 also plays an important part in glucose metabolism. It breaks down incretins, hormones that minimize blood glucose levels.
Research on animals showed that DPP4 impacts the development of fibrosis in organs such as the liver and kidneys. Inhibiting the enzyme, therefore, prevents scarring in diseases that affect these organs. Tripeptide-29 might be beneficial in two ways since diabetes causes kidney fibrosis.
The ability of this peptide to stimulate glucose uptake and minimize fibrosis, both by obstructing DPP4, opens a variety of research opportunities in not only controlling diabetes but its pathologic sequelae as well.
Scientists recently became interested in the role of Tripeptide-29 and other peptides when it comes to protecting skin against aging. Clinical trials suggest that topical peptides can minimize visible signs of aging by improving hydration, reducing skin deformation, and boosting contour.
There is also some evidence that indicates that tripeptides can reduce the appearance of red and brown spots and smooth skin texture. In fact, 90% of test subjects which participated in the study showed improved skin moisturization, while increasing elasticity and flexibility. Nearly 50% of subjects appeared to have better skin in all these animal studies.
Collagen-related peptides with a glycine-proline-hydroxyproline pattern are thought to be linked by cysteine residues, which might help increase platelet secretion and clotting through glycoprotein VI receptors.
Researchers think that this receptor is crucial in blood clotting or homeostasis. The Glycoprotein VI receptor is a membrane of the immunoglobulin superfamily of proteins, which is made up of two subunits called alpha and beta. The alpha one is believed to contain a collagen-binding site, while the beta one signals within the platelet. When the glycoprotein VI receptor binds to collagen, it may cause a series of events, leading to the activation of platelets and the formation of a blood clot.
In animal models, when Tripeptide-29 was applied, it stimulated platelet aggregation and stopped or prevented bleeding. It might boost the formation of thrombi to prevent excessive bleeding.
References:
Useful links
Our support team is at your service, ensuring customer satisfaction.
Our support team is at your service, ensuring customer satisfaction.
